Human Anti-ERBB2 Recombinant Antibody (clone F0178C1)
Recombinant Human Antibody (F0178C1) is capable of binding to ERBB2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ERBB2 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-ERBB2 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody exhibits superior efficacy in blocking HER2/HER3 heterodimerization and signaling, and its use in combination with pertuzumab has a synergistic effect.
Supplier | Creative Biolabs |
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Product # | PABC-157 |
Pricing | Inquiry |
Host | Human |
Target | ERBB2 |
Species Reactivity | Human |
Type | Human IgG |
Applications | Neut |
Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |