Torin 2, Free Base (mTOR Inhibitor XII, CAS 1223001-51-1), >99%

LC Laboratories' Product Number T-8448 - Torin 2, Free Base (mTOR Inhibitor XII, CAS 1223001-51-1), >99% - for research use only. Torin 2 is a highly potent and selective ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitor. Torin 2 inhibited cellular mTOR activity with an IC50 of 0.25 nM and exhibited 800-fold selectivity over PI3K (IC50 = 200 nM) and over 100-fold binding selectivity over 440 other protein kinases. In addition to mTOR, torin 2 also exhibited potent biochemical and cellular activity against phosphatidylinositol-3 kinase-like (PI3K-like) kinase family kinases including ATM (IC50 = 28 nM), ATR (IC50 = 35 nM), and DNA-PK (IC50 = 118 nM), the inhibition of which sensitized cells to irradiation. Treatment with torin 2 for 24 hours resulted in strong growth inhibition of cancer cells in vitro. Single-agent treatment with torin 2 in vivo did not show significant efficacy against KRAS-driven lung tumors, but the combination of torin 2 with mitogen-activated protein/extracellular signal-regulated kinase inhibitor AZD6244 (selumetinib, please see Cat. No. S-4490, Selumetinib, Free Base) demonstrated a significant growth inhibition. Torin 1 and torin 2 are potent antimalarials.

• Supplier: LC Laboratories
• Product #: T-8448
• Sku #: T-8448_25mg