IBC 293
IBC 293, a cell-permeable niacin triazolo derivative, is a potent and highly selective agonist for human orphan G-protein-coupled receptor GPR109b/HM74 expressed in adipocytes with EC50 value of 400 nM. It is selective for GPR109B over niacin receptor GPR109A and β-adrenergic receptor. It inhibits cAMP elevation induced by isoproterenol and forskolin in freshly isolated human adipocytes and GPR109b-expressing CHO cells. It also inhibits forskolin-stimulated cAMP release in Chinese hamster ovary cells. It also inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes. It may be relevant to atherosclerosis and dyslipidemia.
| Supplier | BOC Sciences |
|---|---|
| Product # | 306935-41-1 |
| Pricing | Inquire |
| Cas | 306935-41-1 |
| Molecular Weight | 205.22 |
| Molecular Formula | C10H11N3O2 |
| Canonical SMILES | CC(C)N1C2=C(C=C(C=C2)C(=O)O)N=N1 |