Recombinant Monkey HAVCR2 Protein, Fc-tagged, Alexa Fluor 488 conjugated

Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. TIM-3 thus serves as the surface molecule that distinguishes between the two effector populations derived from naive CD4(+) T-helper cells. TIM-3 is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. Th1 cells produce cytokines (IFN-gamma, interleukin-2, TNF-alpha and lymphotoxin) that are commonly associated with cellmediated immune responses against intracellular pathogens, delayedtype hypersensitivity reactions, and induction of organ-specific autoimmune diseases. It has been identified that galectin-9 is the Tim-3 ligand, and the TIM-3-galectin-9 pathway may serve to inhibit Th1 cellsduring a normal immune response and may be crucial for the induction of peripheral tolerance. Dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

• Supplier: Creative Biomart
• Product #: HAVCR2-213CAF488
• Product Category: Recombinant Protein
• Shipping Country: USA