Rat Anti-Cd8a Recombinant Antibody (clone YTS105.18); scFv Fragment
Unlike YTS156.7, the YTS105.18 epitope is exposed in the pMHCI/CD8αβ complex. The interacting elements between mouse CD8α and the rat antibody YTS105.18 have been identified in the CD8αα/YTS105.18 Fab co-crystal structure. The two potential models for the pMHCI/CD8αβ complex, in which CD8α occupies an α1 or α2 position, respectively, indicate that inhibition of pMHCI/CD8αβ interaction by mAb YTS105.18 would occur only if CD8αβ binds pMHCI with CD8α in the α1 position, whereas YTS105.18 Fab would not block pMHCI/CD8αβ interactions in which CD8α adopts an α2 position.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-S0183-YC-S(P) |
| Pricing | Inquiry |
| Host | Rat |
| Target | Cd8a |
| Species Reactivity | Mouse |
| Type | Rat scFv |
| Applications | ELISA |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |