PTEN (138G6) Rabbit Antibody (BSA and Azide Free)

Supplier CD BioSciences
Product # AMA-0100
Pricing 100 µg, Inquire
Product Category Antibodies
Application WB, IHC
Reactivity Human, Monkey, Mouse, Rat
Host Rabbit
Gene ID 5728
UniProt ID
Source/Isotype Rabbit IgG
MW (Target) 54 kDa
Storage Store at -20°C.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal sequence of human PTEN.
Background PTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers. PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K). PTEN is a major negative regulator of the PI3K/Akt signaling pathway. PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity. PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis.
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