PROTAC Bcl2 degrader-1
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-125876-1 mg |
| CAS # | 2378801-85-3 |
| Pricing | 1 mg, USD $550.0 |
| Biological Activity | PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1]. |
| Purity | 98.28% |
| MWt | 941.84 |
| Formula | C₄₅H₄₅BrN₆O₁₀S |