Apitolisib (GDC-0980)
Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.
Supplier | Selleck Chemicals |
---|---|
Product # | S2696 |
Sku # | S2696-10mM/1mL |
Pricing | 10mM/1mL, $340.00 |