Shikonin
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-N0822-25 mg |
| CAS # | 517-89-5 |
| Pricing | 25 mg, USD $132.0 |
| Synonyms | C.I. 75535; Isoarnebin 4 |
| MWt | 288.3 |
| Formula | C₁₆H₁₆O₅ |
| Biological Activity | Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM[1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor[2] and can also inhibit TNF-α and NF-κB pathway[3]. Shikonin decreases exosome secretion through the inhibition of glycolysis[4]. Shikonin inhibits AIM2 inflammasome activation[7]. |
| Purity | 99.80% |