| Supplier |
CD BioSciences |
| Product # |
AMA-0781 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IP, IF
|
| Product Usage Information Dilution |
Western Blotting (1:1000); Immunoprecipitation (1:100); Immunofluorescence (1:200)
|
| Reactivity |
Mouse
|
| Gene ID |
4988
|
| UniProt ID |
|
| MW (Target) |
70-90 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser377 of human (homologous to Ser375 of mouse) μ-opioid receptor. Antibodies are purified by protein A and peptide affinity chromatography.
|
| Background |
The μ-opioid receptor (MOR) belongs to the superfamily of G-protein-coupled receptors. MOR mediates the analgesic and rewarding effects of morphine and other opiates as well as the actions of several endogenous opioid peptides Upon binding to its ligands, this Gi-coupled receptor inactivates adenylyl cyclase and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades Trafficking of these receptors to and from the plasma membrane and their desensitization play a significant role in morphine tolerance As with other GPCRs, these processes are modulated by phosphorylation at diverse sites within intracellular domains Among other sites, agonist-specific phosphorylation of serine 375 in mouse (serine 377 in human) MOR is essential for its internalization.
|