Wortmannin (KY 12420, CAS 19545-26-7), >99%

LC Laboratories' Product Number W-2990 - Wortmannin (KY 12420), >99% - for research use only. Isolated from the filamentous fungus, Penicillium funiculosum, wortmannin is a potent, irreversible, and specific inhibitor of phosphatidylinositol 3-kinase (PI3-K) with an IC50 of 2-5 nM. Inhibitor of both myosin light chain kinase (IC50 = 200 nM) and phosphatidylinositol 4-kinase at concentrations approximately 100-fold higher than the that required for PI3-K inhibition. Enhances radiation- or serum withdrawal-induced apoptosis through the inhibition of PI3-K/Akt signal transduction cascade and blocks the antiapoptotic effect of cytokines. Wortmannin inhibition of PI3-K also blocks many of the short-term metabolic effects induced by insulin receptor activation in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits platelet activating factor-induced MAP kinase activation in guinea pig neutrophils (200 - 300 nM). Inhibits phospholipase D activation.

• Supplier: LC Laboratories
• Product #: W-2990
• Sku #: W-2990_1g