Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of SK-OV-3 tumor xenografts.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G022R |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | ERBB2 |
| Species Reactivity | Human |