| Supplier |
CD BioSciences |
| Product # |
AMA-0633 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB
|
| Product Usage Information Dilution |
Western Blotting (1:1000)
|
| Reactivity |
Human, Mouse, Rat, Monkey
|
| Gene ID |
8452
|
| UniProt ID |
|
| MW (Target) |
82 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu750 of human Cullin-3. Antibodies are purified by protein A and peptide affinity chromatography.
|
| Background |
CUL3 (Cullin-3) is a member of the cullin-based ubiquitin ligase family. By interacting with Hrt1 and BTB domain containing proteins, the complex functions as a CUL3-based E3 ligase to bring specific substrates to ubiquitinylation and degradation The CUL3 complex has been shown to target many substrates involved in cell cycle progression transcription development and differentiation.
|