Poly(lactide-co-glycolide)
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| Supplier | CD Formulation |
|---|---|
| Product # | PE-0506 |
| Pricing | , Inquire for price |
| product1 | Pharmaceutical Excipients |
| Molecular Formula | / |
| Molecular Weight | / |
| Synonyms | PLGA; Poly(DL-lactic-co-glycolic acid) |
| CAS Number | 26780-50-7 |
| Category | Carrier Excipients |
| UNII | WE369X5600(50:50); 58X445TH30(75:25) |
| Chemical Name | Poly(lactide-co-glycolide) |
| Grade | Pharmceutical Excipients |
| Administration route | Endosinusial; Inyrravitreal; Subcutaneous; Intramuscular |
| Dosage Form | Implant; Injection; soultion, powder, for suspension |
| Stability and Storage Conditions | Sealed, refrigerated or frozen (-20-8°C), bring product close to room temperature before opening to minimize degradation due to moisture condensation. |
| Commonly used amount and the maximum amount | Lactide-co-glycolide (75:25) intramuscular injection maximum dosage of 81.2mg. |
| Source and Preparation | Traditional PLGA preparation methods include ring-opening polymerization and direct polymerization. The ring-opening polymerization method is currently the most commonly used and mature PLGA synthesis method. It is divided into ring-opening random copolymerization and ring-opening homopolymerization. The former synthesizes random copolymers, although different compositions can be synthesized by controlling different feeding ratios. PLGA, but the degree of randomness and compositional reproducibility of the resulting product is difficult to control; the latter synthesizes alternating copolymers, and this PLGA has the advantages of regular structure and stable degradation performance, but this method is not suitable for the complex preparation process. Industrial production. Different from the ring-opening polymerization method, the direct polymerization method prepares PLGA copolymers through solution polycondensation or melt polycondensation. Solution polycondensation has the defects of high pollution and difficult purification due to the use of a large amount of organic solvents. Melt polycondensation relies on a simple and economical process. The route has become the mainstream of related research, and the current research hotspot of melt polycondensation is the preparation of PLGA with high relative molecular mass and controllable structure. |