Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. beta arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

• Supplier: Abbexa Ltd.
• Product #: abx011782-100UL
• Clonality: Monoclonal
• Conjugation: Unconjugated
• Host: Mouse
• Tested Applications: ELISA, WB, IF/ICC
• UniProt Primary AC: P53779
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.