Protein CBFA2T2 (CBFA2T2) Antibody
CBFA2T2 Antibody is a Rabbit Polyclonal antibody against CBFA2T2. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Supplier | Abbexa Ltd. |
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Product # | abx005323-100UL |
Pricing | 100 µl USD $464.0 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Host | Rabbit |
Tested Applications | WB, IF/ICC |
UniProt Primary AC | O43439 |
Dry Ice | No |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |