Recombinant Human Tyrosine Hydroxylase, His-tagged

TH, or TyrH is the rate-limiting enzyme of catecholamine biosynthesis. TH uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme"s activity. The TH enzyme is inhibited in feedback fashion by the catecholamine neurotransmitters. Dopamine binds to TH competitively with tetrahydrobiopterin, and interacts with the R domain. Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. TH is modified in the presence of NO, resulting in nitration of tyrosine residues and the glutathionylation of cysteine residues. TH involved in the pathogenesis of PD at several different levels, in addition to being a promising candidate for developing new treatments of this disease.

• Supplier: Creative Biomart
• Product #: TH-1916H