Zinc Acetate
Zinc acetate occurs as white crystalline, lustrous plates with a faint acetic odor and an astringent taste.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0607 |
| Pricing | , Inquire for price |
| product1 | Other Materials |
| Applications | Zinc acetate has been used as an excipient in a variety of pharmaceutical formulations including topical gels, lotions, and solutions, and subcutaneous injections. It has also been investigated for use in an oral controlled-release formulation for water-soluble drugs in combination with sodium alginate and xanthan gum. Therapeutically, zinc acetate has been used in oral capsules for the treatment of Wilson’s disease. Zinc acetate has also been demonstrated to be effective as a spermicide in vaginal contraceptives. |
| Safety | Zinc acetate is used in topical pharmaceutical formulations and subcutaneous injections, where it is generally regarded as relatively nontoxic and nonirritant when used as an excipient. However, zinc acetate is poisonous by intravenous and intraperitoneal routes; it is also moderately toxic following oral consumption. Zinc acetate: LD50 (rat, oral): 2.510 g/kg LD50 (mouse, IP): 0.057 g/kg Zinc acetate dihydrate: LD50 (mouse, IP): 0.108 g/kg LD50 (mouse, oral): 0.287 g/kg LD50 (rat, IP): 0.162 g/kg LD50 (rat, oral): 0.794 g/kg |
| Incompatibilities | Zinc acetate is incompatible with oxidizing agents, zinc salts, alkalis and their carbonates, oxalates, phosphates, and sulfides. |
| Synonyms | Acetic acid, zinc salt; dicarbomethoxy zinc; zinc acetas dihydricus; zinc (II) acetate; zinc diacetate; zinc ethanoate |
| Category | Emollient; Emulsion Stabilizer; Gelling Agents; Opacifier; Stabilizing Agents |
| UNII | FM5526K07A |
| Chemical Name | Zinc acetate dihydrate ; Zinc acetate anhydrous |
| Grade | Pharmceutical Excipients |
| Administration route | SC ; topical |
| Dosage Form | SC injections; topical lotions and solutions |
| Stability and Storage Conditions | Zinc acetate loses water of hydration above 100℃. Zinc acetate should be stored in an airtight container in a cool, dry, place. |
| Source and Preparation | Zinc acetate is synthesized by reacting zinc oxide with glacial acetic acid, with subsequent crystallization, separation by centrifugation, and drying and milling of the crystals. No organic solvents are used during the synthesis. |