| Supplier |
Creative Peptides |
| Product # |
R1458 |
| CAS # |
1392278-76-0 |
| Pricing |
Inquire
|
| Synonyms |
c(CRGDKGPDC)
|
| MolecularFormula |
C35H57N13O14S2
|
| MolecularWeight |
948.04
|
| Sequence |
- One Letter Code: CRGDKGPDC)
- Three Letter Code: Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys
|
| Storage |
- Protect from light
- Powder -80°C 2 years
- -20°C 1 year
- In solvent -80°C 6 months
- -20°C 1 month
|
| ShippingCondition |
Room temperature in continental US; may vary elsewhere.
|
| Explanation |
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
|
| Application |
iRGD peptides have been shown to increase the accumulation and penetration of anticancer drugs in tumors, but not into normal tissues-regardless of whether the drug is coupled to or administered with the peptide.
|
| CanonicalSMILES |
O=C1[C@@]2([H])N(C(CNC([C@@H](NC([C@](NC(CNC([C@@](CCCNC(N)=N)([H])NC([C@@H](N)CSSC[C@@H](C(O)=O)NC([C@H](CC(O)=O)N1)=O)=O)= O)=O)([H])CC(O)=O)=O)CCCCN)=O)=O)CCC2
|
| Solubility |
H2O : ≥ 50 mg/mL (52.74 mM)
|
| Purity |
98%
|