LIM Domain Kinase 2 (LIMK2) Antibody

LIMK2 Antibody is a Rabbit Polyclonal antibody against LIMK2. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

• Supplier: Abbexa Ltd.
• Product #: abx004143-50UL
• Clonality: Polyclonal
• Conjugation: Unconjugated
• Host: Rabbit
• Tested Applications: WB, IF/ICC
• UniProt Primary AC: P53671
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.