Azacitidine, Free Base (5-AzaC; 5-Azacytidine; 5-AZC; 5-AZCR; 5-Azacitidine; Azacitidinum; Ladakamycin; Ledakamycin; Mylosar; U 18496; Vidaza; WR 183027, CAS 320-67-2), >99%

LC Laboratories' Product Number A-5959 - Azacitidine, Free Base (5-AzaC; 5-Azacytidine; 5-AZC; 5-AZCR; 5-Azacitidine; Azacitidinum; Ladakamycin; Ledakamycin; Mylosar; U 18496; Vidaza; WR 183027, CAS 320-67-2), >99% - for research use only. Azacitidine is a chemical analog of cytidine, a nucleoside found in DNA and RNA. It inhibits DNA methyltransferase and leads to hypomethylation in the promoter region of transcriptionally silenced genes. Azacytidine demonstrated significant cytotoxicity against both conventional therapy-sensitive and therapy-resistant multiple myeloma (MM) cell lines, as well as multidrug-resistant patient-derived MM cells, with IC50 values of approximately 0.8-3 µM. Azacytidine treatment induced DNA double-strand breaks and apoptosis of MM cells. Azacitidine is the active ingredient in the drug product sold under the trade names Mylosar® and Vidaza®. This drug is currently approved in at least one country for use in patients with myelodysplastic syndrome. NOTE: THE AZACITIDINE, FREE BASE RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT MYLOSAR® OR VIDAZA®, AND IS NOT FOR HUMAN USE. Related CAS numbers: 879492-75-8 for the methanesulfonate salt; 1401238-96-7 for the sulfate salt; 1401238-97-8 for the hydrobromide salt. Other CAS numbers previously assigned to 5-Azacitidine, Free Base, namely 52934-49-3 and 292869-98-8, have been deleted by CAS and are no longer in use.

• Supplier: LC Laboratories
• Product #: A-5959
• Sku #: A-5959_1g