LC-2
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-137516-1 mg |
| CAS # | 2502156-03-6 |
| Pricing | 1 mg, USD $550.0 |
| Biological Activity | LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM[1]. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines[2]. |
| MWt | 1132.78 |
| Formula | C₅₉H₇₁ClFN₁₁O₇S |