(S,R,S)-AHPC hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-101763A-5 g |
| CAS # | 1448189-80-7 |
| Pricing | 5 g, USD $2000.0 |
| Synonyms | VH032-NH2 hydrochloride; VHL ligand 1 hydrochloride |
| MWt | 467.02 |
| Formula | C₂₂H₃₁ClN₄O₃S |
| Biological Activity | (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. |
| Purity | ≥98.0% |