Recombinant Human Anti-S. aureus Hla Antibody (MEDI4893)
Recombinant Human Antibody (MEDI4893) is capable of binding to S. aureus Hla, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-S. aureus Hla mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-S. aureus Hla proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. MEDI4893 recognizes a novel epitope in the so-called "rim" domain of AT and exerts its neutralizing effect through a dual mechanism. In particular, MEDI4893 not only sterically blocks binding of AT to its cell receptor but also prevents it from adopting a lytic heptameric trans-membrane conformation.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABL-396 |
| Pricing | Inquiry |
| Host | Human |
| Target | S. aureus Hla |
| Species Reactivity | S. aureus |
| Type | IgG |
| Applications |
|
| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples. |