5-(N,N-Hexamethylene)-amiloride

Supplier MedChemExpress
Product # HY-128067-10 mM * 1 mL
CAS # 1428-95-1
Pricing 10 mM * 1 mL, USD $55.0
Synonyms Hexamethylene amiloride; HMA
MWt 311.77
Formula C₁₂H₁₈ClN₇O
Biological Activity 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2].
Purity ≥98.0%
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