Celecoxib (Celebrex, Celebra, Celocoxib, Celecox, Onsenal, Solexa, SC-58635, YM-177, 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, CAS 169590-42-5), >99%

LC Laboratories' Product Number C-1502 - Celecoxib (Celebrex, Celebra, Celocoxib, Celecox, Onsenal, Solexa, SC-58635, YM-177, 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, CAS 169590-42-5), >99% - for research use only. Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions (e.g. stomach ulcers) that are common with non-selective non-steroidal anti-inflammatory drugs (NSAIDs). Celecoxib and other COX-2 inhibitors increase the risk of myocardial infarction. COX-2 not only plays an important role in inflammation but also is involved in multiple biologic events throughout the tumorigenic process. COX-2 inhibitors may act additively or synergistically with currently used cytotoxics and molecularly targeted agents to prevent and treat cancers. Celecoxib shows competitive kinetics on COX-1 (Ki = 10-16 µM). It also displays an initial competitive interaction with COX-2 (Ki = 11-15 µM), followed by a time-dependent interaction leading to potent inhibition and inactivation (Kinact = 0.03-0.5 s-1). Half-maximal inhibition (IC50) using end-point assays demonstrates the competitive component on COX-1 (IC50 = 4-19 µM) and the inactivation component on COX-2 (IC50 = 0.003-0.006 µM). Celecoxib is the active ingredient in the drug sold under the trade name Celebrex or Celebra in some countries. It has been approved ina at least one country for treatment of patients with osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and it is also used to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

• Supplier: LC Laboratories
• Product #: C-1502
• Sku #: C-1502_2g