(R)-CR8
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-18340-10 mM * 1 mL |
| CAS # | 294646-77-8 |
| Pricing | 10 mM * 1 mL, USD $522.0 |
| Synonyms | CR8, (R)-Isomer |
| MWt | 431.53 |
| Formula | C₂₄H₂₉N₇O |
| Biological Activity | (R)-CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K[3]. |
| Purity | ≥98.0% |