COTI-2

Supplier MedChemExpress
Product # HY-19896-5 mg
CAS # 1039455-84-9
Pricing 5 mg, USD $75.0
Biological Activity COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation[1][2][3].
Purity 98.96%
MWt 366.48
Formula C₁₉H₂₂N₆S
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