| Supplier |
Creative Peptides |
| Product # |
R1874 |
| CAS # |
1211877-36-9 |
| Pricing |
Inquire
|
| MolecularFormula |
C26H41N3O5
|
| MolecularWeight |
475.6
|
| Sequence |
- One Letter Code: Cbz-LLL
- Three Letter Code: Cbz-Leu-D-Leu-Leu-al
|
| Storage |
Store at -20°C
|
| ShippingCondition |
Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
|
| Explanation |
(R)-MG132 is a potent, reversible, and cell-permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively.
|
| ChemicalName |
benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
|
| Activity |
Potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.
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| InChI |
InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
|
| InChIKey |
TZYWCYJVHRLUCT-ZRBLBEILSA-N
|
| CanonicalSMILES |
CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
|
| Solubility |
Soluble to 100 mM in DMSO and to 20 mM in ethanol
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| IsomericSMILES |
CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
|
| Purity |
≥97% by HPLC
|