Genz-123346 Free base
Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.
| Supplier | BOC Sciences |
|---|---|
| Product # | 491833-30-8 |
| Pricing | Inquire |
| Cas | 491833-30-8 |
| Molecular Weight | 418.57 |
| Molecular Formula | C24H38N2O4 |
| Canonical SMILES | CCCCCCCCC(=O)NC(CN1CCCC1)C(C2=CC3=C(C=C2)OCCO3)O |