Recombinant Mouse Anti-DENV E protein Antibody (E53)
Recombinant Mouse Antibody (E53) is capable of binding to DENV E protein, expressed in Chinese Hamster Ovary cells (CHO). E53, a highly cross-reactive fusion-loop antibodies, bind to a conserved region of the flavivirus E protein and are generally weakly neutralizing. Because of their cross-reactivity, fusion-loop antibodies generated during a primary DENV infection should bind to partially or mostly immature viruses produced during a secondary infection. Therefore, these fusion-loop antibodies may promote ADE of infection by augmenting attachment and/or entry of partially immature virions. Indeed, it has been shown recently that fusion-loop-specific MAbs promote ADE in animals.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABW-146 |
| Pricing | Inquiry |
| Host | Mouse |
| Target | DENV E protein |
| Species Reactivity | DENV, WNV |
| Type | IgG |
| Applications | Inhib |
| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples. |