SB269970 HCl
SB269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1772 |
| CAS # | 261901-57-9 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | SB269970; SB 269970; SB-269970; GR125743; GR-125743; GR 125743; SB269970 HCl. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H29ClN2O3S |
| Exact Mass | 352.1821 |
| Molecular Weight | 388.951 |
| Elemental Analysis | C, 55.58; H, 7.52; Cl, 9.11; N, 7.20; O, 12.34; S, 8.24 |
| IUPAC/Chemical Name | 3-[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride |
| InChi Key | XQCJOYZLWFNDIO-PKLMIRHRSA-N |
| InChi Code | InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1 |
| SMILES Code | OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |