ML-365
ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay). It possesses more than 60-fold selectivity for inhibition of TASK1 over TASK3. It displays little or no inhibition at 30 μM of more distantly related Kir2.1, voltage-gated potassium channel, KQT-like subfamily, member 2 (KCNQ2) and human ether-a go-go-related gene (hERG). It is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies.
| Supplier | BOC Sciences |
|---|---|
| Product # | 947914-18-3 |
| Pricing | Inquire |
| Cas | 947914-18-3 |
| Molecular Weight | 360.41 |
| Molecular Formula | C22H20N2O3 |
| Canonical SMILES | CC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2)NC(=O)C3=CC=CC=C3OC |