A-83-01
A 83-01 is an inhibitor of TGF-β type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition.
| Supplier | BOC Sciences |
|---|---|
| Product # | B0084-155117 |
| Pricing | Inquire |
| Cas | 909910-43-6 |
| Molecular Weight | 421.52 |
| Molecular Formula | C25H19N5S |
| Canonical SMILES | CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5 |