BTRX-335140
BTRX-335140, also known as CYM-53093, a potent and selective KOR antagonist with IC50 (KOR)=0.8 nM. BTRX-335140 endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD131 |
| CAS # | 2244614-14-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | BTRX-335140; BTRX 335140; BTRX335140; CYM-53093; CYM 53093; CYM53093; Navacaprant |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C25H32FN5O2 |
| Exact Mass | 453.254 |
| Molecular Weight | 453.5624 |
| Elemental Analysis | C, 66.20; H, 7.11; F, 4.19; N, 15.44; O, 7.05 |
| IUPAC/Chemical Name | 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4 amine |
| InChi Key | CQOJHAJWCDJEAT-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C25H32FN5O2/c1-4-17-13-20-15(2)22(25-27-16(3)30-33-25)24(29-23(20)21(26)14-17)31-9-5-18(6-10-31)28-19-7-11-32-12-8-19/h13-14,18-19,28H,4-12H2,1-3H3 |
| SMILES Code | CC1=NOC(C2=C(C)C3=CC(CC)=CC(F)=C3N=C2N4CCC(NC5CCOCC5)CC4)=N1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |