Recombinant Human FMS (N-GST tag)

FMS is a proto-oncogene that encodes the tyrosine kinase transmembrane receptor for colony stimulating factor 1 (CSF1). FMS is homodimeric that contains a so-called kinase insert domain and is a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. FMS mediates most if not all of the biological effects of CSF1 which control the production, differentiation, and function of cell of the monocyte/macrophage lineage. Mutations in FMS have been associated with providing sustained signals for cell growth and a predisposition to myeloid malignancy.

• Supplier: Amerigo Scientific
• Product #: Z500149