| Supplier |
Creative Peptides |
| Product # |
R1937 |
| CAS # |
203787-91-1 |
| Pricing |
Inquire
|
| Synonyms |
sodium 8-(2-hydroxybenzamido)octanoate; SNAC
|
| MolecularFormula |
C15H20NNaO4
|
| MolecularWeight |
301.31
|
| Explanation |
Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation.
|
| ChemicalName |
sodium;8-[(2-hydroxybenzoyl)amino]octanoate
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| Application |
Delivery agent
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| InChI |
InChI=1S/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1
|
| InChIKey |
UOENJXXSKABLJL-UHFFFAOYSA-M
|
| CanonicalSMILES |
C1=CC=C(C(=C1)C(=O)NCCCCCCCC(=O)[O-])O.[Na+]
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| Solubility |
10 mM in DMSO
|
| Reference |
- 1. Riley MGI, et, al. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats. Int J Toxicol. Jul-Aug 2009; 28(4):278-93.
- 2. Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10). Pharmaceutics. 2019 Feb 13; 11(2):78.
- 3. Li Y, et, al. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules. 2018 Nov 16; 23(11):2990.
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