Anti-CGB immunotoxin PiPP (scFv)-PE

This immunotoxin was achieved by conjugating/fusing the Anti-CGB scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human chorionic gonadotropin (hCG) expressing cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating T-lymphoblastic leukemia and lung carcinoma.
Supplier Creative Biolabs
Product # AGTO-G012E
Pricing Inquiry
Applications This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Host Mouse
Target CGB
Species Reactivity Human
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