Recombinant Human Anti-HIV-1 gp120 Antibody (PGT 135)
Recombinant Human Antibody (PGT 135) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-HIV-1 gp120 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The PGT 135 epitope includes three glycans and protein segments that differs substantially from other Asn332-dependent epitopes and enables PGT 135 accommodation of HIV-1 Env glycan heterogeneity through some variation its angle of approach to the gp120 surface.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABZ-168 |
| Pricing | Inquiry |
| Host | Human |
| Target | HIV-1 gp120 |
| Species Reactivity | HIV-1 |
| Type | IgG |
| Applications |
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| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples. |