Anti-CD72 immunotoxin J3-109 (IgG)-PAP

This immunotoxin was achieved by conjugating/fusing the Anti-CD72 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of acute lymphoblastic leukemias (ALL).
Supplier Creative Biolabs
Product # AGTO-G083P
Pricing Inquiry
Applications This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Host Mouse
Target CD72
Species Reactivity Human
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