Anti-CD72 immunotoxin J3-109 (IgG)-PAP
This immunotoxin was achieved by conjugating/fusing the Anti-CD72 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of acute lymphoblastic leukemias (ALL).
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-G083P |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | CD72 |
| Species Reactivity | Human |