Methionine

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Methionine occurs as a white or almost white, crystalline powder or colorless crystals.
Supplier CD Formulation
Product # PE-0424
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product1 Pharmaceutical Excipients
Molecular Formula C5H11NO2S
Molecular Weight 149.21
Applications Methionine is used in oral pharmaceutical formulations as a flavoring agent. It has been included in parenteral formulations as a pH controlling agent, and it has also been used experimentally as an antioxidant with antibodies. Methionine is also used therapeutically in oral tablets.
Safety
  • Methionine is used in oral pharmaceutical formulations. The pure form of methionine is mildly toxic by ingestion and by the IP route.
  • LD50 (rat, IP): 4.328 g/kg
  • LD50 (rat, oral): 36 g/kg
Incompatibilities Methionine is incompatible with strong oxidizing agents.
Synonyms α-Amino-g-methylmercaptobutyric acid; (S)-2-amino-4- (methylthio)butanoic acid; 2-amino-4-(methylthio)butyric acid; L - methionine; methioninum; g-methylthio-a-aminobutyric acid.
CAS Number 63-68-3
Category Flavoring agent
UNII AE28F7PNPL
Chemical Name (2S)-2-Amino-4-methylsulfanylbutanoic acid
Grade Pharmceutical Excipients
Administration route Oral; Injection
Dosage Form Oral tablets; Injection solutions; powders for reconstitution
Stability and Storage Conditions Methionine is sensitive to light and should be stored in a cool, dark place.
Source and Preparation Numerous methods have been described for manufacture of methionine, including hydrolysis of methionine amide and 5-(methylmercaptoethyl)-hydantoin.
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