TH5427 hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-125209A |
| CAS # | 2253744-57-7 |
| Pricing | inquire |
| Biological Activity | TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1]. |
| MWt | 527.79 |
| Formula | C₂₀H₂₁Cl₃N₈O₃ |