Tubastatin A HCl salt
Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.
| Supplier | BOC Sciences |
|---|---|
| Product # | 1310693-92-5 |
| Pricing | Inquire |
| Cas | 1310693-92-5 |
| Molecular Weight | 371.865 |
| Molecular Formula | C20H22ClN3O2 |
| Canonical SMILES | CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl |