HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB) Antibody

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

• Supplier: Abbexa Ltd.
• Product #: abx028893-400UL
• Clonality: Polyclonal
• Conjugation: Unconjugated
• Host: Rabbit
• Tested Applications: ELISA, WB
• UniProt Primary AC: P28068
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.