BMS-902483
BMS-902483 is a potent α7 partial agonist, which improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm. Preclinical and early clinical data suggest that α7 nicotinic acetylcholine receptor (nAChR) agonists have potential for the treatment of cognitive and negative symptoms in schizophrenia patients
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1418 |
| CAS # | 1192810-88-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | BMS-902483; BMS 902483; BMS902483. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H20N4O |
| Exact Mass | 308.1637 |
| Molecular Weight | 308.385 |
| Elemental Analysis | C, 70.11; H, 6.54; N, 18.17; O, 5.19 |
| IUPAC/Chemical Name | (1S,2R,4S)-N-(isoquinolin-3-yl)-4'H-4-azaspiro[bicyclo[2.2.2]octane-2,5'-oxazol]-2'-amine |
| InChi Key | ZDTPXUKLGIDOCS-SFHVURJKSA-N |
| InChi Code | InChI=1S/C18H20N4O/c1-2-4-14-10-19-16(9-13(14)3-1)21-17-20-11-18(23-17)12-22-7-5-15(18)6-8-22/h1-4,9-10,15H,5-8,11-12H2,(H,19,20,21)/t18-/m0/s1 |
| SMILES Code | [C@@H]1(CC2)[C@@]3(OC(NC4=CC5=C(C=N4)C=CC=C5)=NC3)C[N@]2CC1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |