HDAC4 / 5 / 9 (pS246 / 259 / 220) Antibody

HDAC4/5/9 (pS246/259/220) Antibody is a Rabbit Polyclonal antibody against HDAC4/5/9 (pS246/259/220). Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

• Supplier: Abbexa Ltd.
• Product #: abx000331-20UL
• Clonality: Polyclonal
• Conjugation: Unconjugated
• Host: Rabbit
• Tested Applications: WB, IHC
• UniProt Primary AC: P56524, Q9UQL6, Q9UKV0
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.