GSK-189254 free base
GSK-189254 is a potent and selective H3-receptor inverse agonist. It has subnanomolar affinity for the H3 receptor and selectivity of over 10,000x for H3 over other histamine receptor subtypes. Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. GSK-189,254 and several other related drugs are currently being investigated as a treatment for Alzheimer's disease and other forms of dementia, as well as possible use in the treatment of conditions such as narcolepsy, or neuropathic pain which do not respond well to conventional analgesic drugs.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1525 |
| CAS # | 720690-73-3 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | GSK189254; GSK-189254; GSK 189254; GSK-189254 free base; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H25N3O2 |
| Exact Mass | 351.19468 |
| Molecular Weight | 351.45 |
| Elemental Analysis | C, 71.77; H, 7.17; N, 11.96; O, 9.10 |
| IUPAC/Chemical Name | 6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)oxy)-N-methylnicotinamide |
| InChi Key | WROHEWWOCPRMIA-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C21H25N3O2/c1-22-21(25)17-6-8-20(23-14-17)26-19-7-5-15-9-11-24(18-3-2-4-18)12-10-16(15)13-19/h5-8,13-14,18H,2-4,9-12H2,1H3,(H,22,25) |
| SMILES Code | O=C(NC)C1=CN=C(OC2=CC=C3CCN(C4CCC4)CCC3=C2)C=C1 |
| Appearance | solid powder |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >5 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |