MK-0249 free base
MK-0249 is a histamine H3 inverse antagonist. Current antipsychotic treatments have little impact on the cognitive deficits associated with schizophrenia. It has been proposed that agents which promote histamine release may enhance cognition and, therefore, the H3 inverse agonist MK-0249 might improve cognitive deficits in patients with schizophrenia.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1558 |
| CAS # | 862309-06-6 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | MK0249; MK 0249; MK-0249 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H24F3N3O2 |
| Exact Mass | 431.1821 |
| Molecular Weight | 431.4508 |
| Elemental Analysis | C, 64.03; H, 5.61; F, 13.21; N, 9.74; O, 7.42 |
| IUPAC/Chemical Name | 2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one |
| InChi Key | DDDZBLNULGDPGA-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3 |
| SMILES Code | O=C1N(C2=CC=C(OCCCN3CCCC3)C=C2)C(C)=NC4=C1C(C(F)(F)F)=CC=C4 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |