Rat Anti-Cd8a Recombinant Antibody (clone YTS105.18); Fab Fragment

Unlike YTS156.7, the YTS105.18 epitope is exposed in the pMHCI/CD8αβ complex. The interacting elements between mouse CD8α and the rat antibody YTS105.18 have been identified in the CD8αα/YTS105.18 Fab co-crystal structure. The two potential models for the pMHCI/CD8αβ complex, in which CD8α occupies an α1 or α2 position, respectively, indicate that inhibition of pMHCI/CD8αβ interaction by mAb YTS105.18 would occur only if CD8αβ binds pMHCI with CD8α in the α1 position, whereas YTS105.18 Fab would not block pMHCI/CD8αβ interactions in which CD8α adopts an α2 position.

• Supplier: Creative Biolabs
• Product #: HPAB-S0183-YC-F(E)
• Host: Rat
• Target: Cd8a
• Species Reactivity: Mouse
• Type: Rat Fab
• Applications: ELISA
• Storage: Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.