IRE1α kinase-IN-1
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-136735 |
| CAS # | 2328097-41-0 |
| Pricing | inquire |
| Biological Activity | IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM)[1]. |
| MWt | 504.99 |
| Formula | C₂₆H₂₆ClFN₈ |